Functional Alterations of Intestinal P-Glycoprotein under Diabetic Conditions
نویسندگان
چکیده
منابع مشابه
[Altered intestinal P-glycoprotein expression levels affect pharmacodynamics under diabetic condition].
P-glycoprotein (P-gp), one of the important drug-efflux pumps, is known to affect pharmacokinetics and pharmacodynamics of P-gp substrate drugs. We have previously reported that intestinal P-gp expression levels are transiently decreased in streptozotocin (STZ)-induced type 1 diabetic mouse model. Herein, we examined the analgesic effects of orally administered morphine and its pharmacokinetic ...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2013
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b13-00369